| Antigenic Specificity |
ABBA |
| Clone |
polyclonal |
| Host Species |
Rabbit |
| Reactive Species |
human, mouse, rat |
| Isotype |
n/a |
| Format |
serum |
| Size |
100 µl |
| Applications |
Western Blotting;Immunocytochemistry;Immunohistochemistry |
| Description |
Radial glia play key roles in neuronal migration, axon guidance, and neurogenesis during development of the central nervous system. However, the molecular mechanisms regulating growth and morphology of these extended cells are unknown. ABBA, a novel member of the IRSp53/MIM protein family, is enriched in different types of radial glia. ABBA binds ATP-actin monomers with high affinity and deforms PIP2-rich membranes in vitro through its WH2 and IMdomains, respectively. In radial glia-like C6-R cells, ABBA localizes to the interface between the actin cytoskeleton and plasma membrane, and its depletion by RNAi leads to defects in lamellipodial dynamics and process extension. Together, ABBA acts as a novel regulator of actin and plasma membrane dynamics in radial glial cells, and provides evidence that the membrane binding/deformation activity is critical for the cellular functions of IRSp53/MIM/ABBA family proteins |
| Catalog # |
AB2209 |
| Price |
please inquire |
| Other Names |
actin-bundling protein with BAIAP2 homology |
| Supplier Data Page |
Anti-ABBA from EMD MILLIPORE |
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