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Anti-14-3-3 Polyclonal Antibody from MYBIOSOURCE, LLC
Anti-14-3-3 Polyclonal Antibody from MYBIOSOURCE, LLC
| Antigenic Specificity |
14-3-3 |
| Clone |
polyclonal |
| Host Species |
Sheep |
| Reactive Species |
sheep |
| Isotype |
n/a |
| Format |
purified IgG - liquid |
| Size |
0.1 mg |
| Applications |
Western Blot |
| Description |
Specificity: 14-3-3. Species Cross Reactivity: Reacts with: Human, Bovine, Mouse, Rat, RabbitBased on sequence similarity, is expected to react with: Mammals N.B. Antibody reactivity and working conditions may vary between species. Specificity Note: This product recognises the 14-3-3 isoforms beta and zeta which are phosphorylated at serine 185. The members of the 14-3-3 family of proteins are highly conserved and are involved in multiple signalling pathways. The phosphorylated forms of beta and zeta 14-3-3 are found endogenously in brain tissue. Immunogen: Synthetic peptide corresponding to 14-3-3 beta and zeta phosphorylated at serine 185. Peptide sequence: EILNSPEKAC. Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Subunit structure: Homodimer. Heterodimerizes with YWHAE By similarity. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58 By similarity. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with CDK16 and with WEE1 (C-terminal). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with BSPRY. Interacts with Thr-phosphorylated ITGB2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional acivity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with AANAT ('Thr-31' phosphorylated form); the interaction modulates AANAT enzymatic activity through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT ('Ser-205' phosphorylated form), can bind the other YWHAZ monomer with similar effect. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization By similarity. Interacts with GAB2 By similarity. Subcellular location: Cytoplasm. Melanosome. Note: Located to stage I to stage IV melanosomes By similarity. Tissue specificity: Highly expressed in brain (at protein level). Post-translational modification: The delta, brain-specific form differs from the zeta form in being phosphorylated By similarity. Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1 By similarity. Ref.3 Sequence similarities: Belongs to the 14-3-3 family. |
| Catalog # |
MBS221344 |
| Price |
$440 |
| Other Names |
14-3-3 protein zeta/delta; 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1, 14-3-3, YWHAZ |
| Supplier Data Page |
Anti-14-3-3 from MYBIOSOURCE, LLC |
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