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Anti-14-3-3 Polyclonal Antibody from MYBIOSOURCE, LLC
Anti-14-3-3 Polyclonal Antibody from MYBIOSOURCE, LLC
| Antigenic Specificity |
14-3-3 |
| Clone |
polyclonal |
| Host Species |
Rabbit |
| Reactive Species |
sheep |
| Isotype |
n/a |
| Format |
serum |
| Size |
0.1 ml |
| Applications |
Immunoprecipitation, Immunohistochemistry (Formalin Fixed-Paraffin Embedded), Western Blot |
| Description |
Specificity: 14-3-3. Species Cross Reactivity: Reacts with: Human, Bovine, Rat, Mouse, Amphibia, Chicken, Fungal, Plants, ReptileBased on sequence similarity, is expected to react with: Mammals N.B. Antibody reactivity and working conditions may vary between species. Specificity Note: This product recognises all isoforms of the 14-3-3 protein family. The 14-3-3 family consists of 30kD proteins that are involved in multiple cellular processes including protein kinase signalling pathways, regulation of cell cycle progression, transcription and intracellular trafficking. Protein interactions with 14-3-3 show distinct preferences for its different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. Immunogen: Mixture of synthetic peptides corresponding to all isoforms of sheep 14-3-3. Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis By similarity. Subunit structure: Homodimer. Interacts with SSH1 and TORC2/CRTC2. Interacts with ABL1 (phosphorylated form); the interaction results in cytoplasmic location of ABL1 and inhition of cABL-mediated apoptosis. Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues. Interacts with GAB2 and YAP1 By similarity. Subcellular location: Cytoplasm. Melanosome By similarity. Post-translational modification: Form alpha differs from form beta in being phosphorylated. Ref.3 Sequence similarities: Belongs to the 14-3-3 family. |
| Catalog # |
MBS222337 |
| Price |
$470 |
| Other Names |
14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha; Protein kinase C inhibitor protein 1, 14-3-3, YWHAB |
| Supplier Data Page |
Anti-14-3-3 from MYBIOSOURCE, LLC |
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