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Anti-ABIN-1 Monoclonal Antibody from MYBIOSOURCE, LLC
Anti-ABIN-1 Monoclonal Antibody from MYBIOSOURCE, LLC
| Antigenic Specificity |
ABIN-1 |
| Clone |
6A2 |
| Host Species |
Mouse |
| Reactive Species |
human |
| Isotype |
IgG2a,k |
| Format |
affinity purified |
| Size |
0.1 mg |
| Applications |
ELISA, Western Blot, Immunoprecipitation |
| Description |
Anti - ABIN-1 (A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) Activation). Specificity: Recognizes the ~80kD human ABIN-1 protein. Bands of unknown origin at ~180kD and >250kD were observed in Western Blots using HEK-293 cell lysates. Species sequence homology: mouse and rat 100%.. A20-binding inhibitor of NFkB activation (ABIN-1) is involved in NFkB-dependent gene expression and plays an important role in numerous cellular processes including stress responses, inflammation and cell proliferation. ABIN-1 increases cell surface CD4 (T4) antigen expression, and it interacts with HIV-1 matrix protein and is packaged into virions. Overexpression of ABIN-1can.inhibit viral replication. ABIN-1 may also regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of GAG polyprotein and viral genomic RNA during virion production. ABIN-1 is strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. |
| Catalog # |
MBS603658 |
| Price |
$540 |
| Other Names |
ABIN-1 (A-20 binding Inhibitor of Nuclear Factor-kappaB (NF-kB) Activation); ABIN-1; |
| Supplier Data Page |
Anti-ABIN-1 from MYBIOSOURCE, LLC |
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