| Antigenic Specificity |
ABCC5 |
| Clone |
M5II-54 |
| Host Species |
Rat |
| Reactive Species |
human |
| Isotype |
IgG2a |
| Format |
IgG purified |
| Size |
0.2ml |
| Applications |
M5II-54 has potential value for detection of MRP5-mediated drug-resistance samples. Immunocytochemistry: use 1:20-50 dil. on acetone fixed cytospin preparations. For immunohistochemistry: M5II-54 (use 1:20) on acetone fixed frozen sections can be followed |
| Description |
Specificity: M5II-54 reacts with an internal epitope of MRP5, a 190-200 kD transmembrane protein that is closely related to the multidrug resistance protein MRP. M5II-54 was raised against a bacterial fusion protein of MRP5, containing amino acids 722-910 of the protein. M5I-1 does not cross-react with the human MDR1, MRP1, MRP2 or MRP3 gene products. Immunogen: The antibody reacts with the MRP5 antigen. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq] |
| Catalog # |
NBP1-42345 |
| Price |
$295.00 |
| Other Names |
ABC33, ABC33, ABCC5, ATP-binding cassette, canalicular multispecific organic anion trans, DKFZp686C1782, EST277145, MOATC, MOAT-C, MRP5, pABC11, SMRP, member 5, sub-family C, sub-family C (CFTR/MRP) |
| Supplier Data Page |
Anti-ABCC5 from NOVUS BIOLOGICALS, LLC |
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