Anti-ABL2 Monoclonal Antibody from PROMAB BIOTECHNOLOGIES, INC.

PROMAB BIOTECHNOLOGIES, INC.

PROMAB BIOTECHNOLOGIES, INC.

5221 Central Avenue, Suite 200

Richmond CA 94804

Phone: 510-860-4615

Phone: 866-339-0871

Fax: 510-740-3625

Email: info@promab.com

Website: http://www.promab.com

Anti-ABL2 Monoclonal Antibody from PROMAB BIOTECHNOLOGIES, INC.

Antigenic Specificity	ABL2
Clone	1H1
Host Species	Mouse
Reactive Species	human, mouse
Isotype	IgG1
Format	ascites containing 0.03% sodium azide.
Size	0.1ml
Applications	Western Bloting: 1/500 - 1/2000.Immunofluorescence: 1/200 - 1/1000.ELISA: Propose dilution 1/10000.Not yet tested in other applications.Determining optimal working dilutions by titration test.
Description	Immunogen: Purified recombinant fragment of ABL2 expressed in E. Coli. ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases. ABL2 and c-Abl share 89%, 90 and 93% identity in their SH3, SH2 and tyrosine domain, but only 29% identity in the carboxy-terminal half. The human c-Abl and ABL2 genes are expressed ubiquitously. ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization. c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl. Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML). The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.
Catalog #	20429
Price	$280
Other Names	ARG, ABLL, FLJ22224, FLJ31718, FLJ41441
Supplier Data Page	Anti-ABL2 from PROMAB BIOTECHNOLOGIES, INC.

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