Anti-ADAM15 Polyclonal Antibody from GENWAY BIOTECH INC.

Antigenic Specificity ADAM15
Clone polyclonal
Host Species Rabbit
Reactive Species n/a
Isotype n/a
Format Immunogen affinity purified
Size 0.025 mg
Applications Application Note: WB: Use at a dilution of 1/1000. This concentration is determined for tissue or cell lysates using an alkaline phosphatase conjugated secondary antibody and BCIP/NBT as the substrate. A starting dilution of 1/5000 of the antibody is recommended for chemilStorage Buffer: Preservative: 0.05% Sodium Azide; Constituents: 50% Glycerol. PBS
Description Function: May be involved in cell-surface proteolysis. cell adhesion or intracellular protein maturation.Cofactor: Binds 1 zinc ion per subunit (By similarity).Subunit: Interacts with ITAGV-ITGB3 (vitronectin receptor). PACSIN3 and SNX9. PACSIN3 and SNX9 preferentially bind the precursor but not the processed form of ADAM15. suggesting that the interaction occurs in a secretory pathway compartment prior to the medial Golgi (By similarity). Interacts specifically with Src family protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A.Subcellular Location: Membrane; Single-pass type I membrane protein.Tissue Specificity: Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes.Domain: The cytoplasmic domain interacts with endophilin I and sorting nexin 9 (By similarity).Domain: Desintegrin domain binds to integrin alphaV-beta3.Ptm: The precursor is cleaved by a furin endopeptidase (By similarity).Ptm: Phosphorylation increases association with PTKs.Similarity: Contains 1 disintegrin domain.Similarity: Contains 1 EGF-like domain.Similarity: Contains 1 peptidase M12B domain [view classification].
Catalog # 18-272-195434
Price $290.00
Other Names ADAM15, MDC15, ADAM15; EC 3.4.24.-; A disintegrin and metalloproteinase domain 15; Metalloproteinase-like. disintegrin-like. and cysteine-rich protein 15; MDC-15; Metalloprotease RGD disintegrin protein; Metargidin
Supplier Data Page Anti-ADAM15 from GENWAY BIOTECH INC.

GENWAY BIOTECH INC.

6777 Nancy Ridge Drive

San Diego CA 92121

Phone: 877-4-GenWay

Fax: 858-458-0833

Email: sales@genwaybio.com

Website: http://www.genwaybio.com

 
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