Anti-Human CD49b (Integrin alpha2, ITGA2, alpha-2 subunit of VLA-2 Receptor, Platelet Antigen B) (PE) Monoclonal Antibody from UNITED STATES BIOLOGICAL

Antigenic Specificity Human CD49b (Integrin alpha2, ITGA2, alpha-2 subunit of VLA-2 Receptor, Platelet Antigen B) (PE)
Clone 3H1478
Host Species Mouse
Reactive Species human monkey
Isotype IgG1
Format phycoerythrin (RPE) conjugate. purified by Protein G affinity chromatography.
Size 100 tests
Applications FC
Description Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing alpha integrin 2 combines with beta integrin 1 to form a collagen-binding integrin referred to as glycoprotein Ia/IIa (gpIa/IIa) when expressed on platelets, and very late (activation) antigen 2 ('VLA-2') when found on T-cells. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. CD49b is expressed approximately 50% of monocytes and most adherent cell lines.CD49b forms a non-covalent association with the 130kD VLA beta chain (CD29) in the VLA-2 complex. The CD49b/CD29 complex is also known as a2/b1 and VLA-2. The complex mediates binding of cells to collagen (types I, II, III, and IV) and to laminin. The complex of CD49b associated with CD29 (integrin b1) is a receptor for laminin and collagen. This complex is expressed by some CD4-positive T-cells, natural killer cells, epithelial cells and platelets.Recommended Secondary Antibody:IgG1: RPEFusion Partners: Spleen cells from immunized mice were fused with cells of the mouse NS1 myeloma cell line.Recommended Negative Controls: Mouse IgG1 Negative ControlApplications:Flow Cytometry: 1:50-1:100. Use 10ul of the suggested working dilution to label 10e6 cells in 100ul. Optimal working dilutions to be determined by researcher.Storage and Stability:May be stored at 4?C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20?C. Aliquots are stable for at least 12 months at -20?C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalog # C2404-06Q
Price n/a
Other Names n/a
Supplier Data Page Anti-Human CD49b (Integrin alpha2, ITGA2, alpha-2 subunit of VLA-2 Receptor, Platelet Antigen B) (PE) from UNITED STATES BIOLOGICAL

UNITED STATES BIOLOGICAL

P.O. Box 261

Swampscott MA 01907

Phone: 781-639-5092

Phone: 800-520-3011

Fax: 781-639-1768

Email: chemicals@usbio.net

Website: http://www.usbio.net

 
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