A77 1726 from CALBIOCHEM/EMD BIOSCIENCES
| Name | A77 1726 |
|---|---|
| Description | Leflunomide metabolite that blocks TNF-dependent NF-κB activation and gene expression. Inhibits the activity of dihydroorotate dehydrogenase (DHO-DH; IC50 = 220 nM). Reported to reduce IFN-γ-induced expression of iNOS in L929 fibroblasts. Inhibits IL-1β-induced activation of COX-2 and PGE2 synthesis (IC50 = 130 nM) in A549 cells. Also inhibits the IL-2-induced tyrosine phosphorylation of JAK1 and JAK3. |
| Size | n/a |
| Applications | n/a |
| Catalog # | 100128 |
| Price | n/a |
| Other Names | N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotoamide |
| Supplier Data Page | A77 1726 from CALBIOCHEM/EMD BIOSCIENCES |
CALBIOCHEM/EMD BIOSCIENCES
an Affiliate of Merck KGaA, Darmstadt, Germany
P.O. Box 12087
La Jolla CA 92039-2087
Phone: 858-450-9600
Phone: 800-854-3417
Fax: 858-453-3552
Website: http://www.calbiochem.com
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