Bufalin from CALBIOCHEM/EMD BIOSCIENCES
| Name | Bufalin |
|---|---|
| Description | A cardiotonic steroid isolated from toads of Bufo species that potently inhibits ouabain-sensitive Na+,K+-ATPase activity (IC50 = 1.4 nM). Induces apoptosis in various human cell lines such as leukemia HL-60 and U937 cells by altering the expression of apoptosis-related genes. Reported to stimulate the activities of p21 activated kinase (PAK) and c-Jun Kinase (JNK) in leukemic cell lines. Induces a transient increase in the expression of Tiam1 mRNA in U937 cell lines (~100 nM). Bufalin also down-regulates gene expression of the intracellular signaling protein 14-3-3 in rat lens, probably a consequence of Na+,K+-ATPase inhibition. Reduces the level of topoisomerase II in human leukemia cells. |
| Size | n/a |
| Applications | n/a |
| Catalog # | 203900 |
| Price | n/a |
| Other Names | 5β, 20(22)-Bufadienolide-3β, 14-diol |
| Supplier Data Page | Bufalin from CALBIOCHEM/EMD BIOSCIENCES |
CALBIOCHEM/EMD BIOSCIENCES
an Affiliate of Merck KGaA, Darmstadt, Germany
P.O. Box 12087
La Jolla CA 92039-2087
Phone: 858-450-9600
Phone: 800-854-3417
Fax: 858-453-3552
Website: http://www.calbiochem.com
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