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Apamin from ALOMONE LABS
Apamin from ALOMONE LABS
| Name |
Apamin |
| Description |
Purity: >98%. Effective Concentration: 100 nM - 1 μM. Apamin. Small conductance Ca\2+\ activated K+ channels (SK) blocker. Apamin is a natural peptide isolated and purified from Apis mellifera bee venom. Apamin blocks small conductance Ca\2\+\ activated K+ channels (SK). It is specific for the SK1-3 isoforms, but ineffective in blocking other calcium activated K+ channels (see for example). In mammalian cell lines Apamin blocks expressed hSK1 with an IC50 of ~10nM , rSK1 and rSK2 with IC50 of ~3 and <1 nM respectively and liver rSK3 with IC50 <1nM. In Jurkat T-cells 5nM of apamin blocks 70% of hSK2 currents. Blocking these channels with Apamin influences slow after hyperpolarization in neurons (see for example), as well as smooth muscle contraction and catecholamine secretion in adrenal gland. Electrophysiology, application of long (~400ms) voltage ramps, covering the whole physiological range (-160 to +40mV), in the whole cell patch-clamp or voltage clamp configurations, before and after bath perfusion of the drug, allows the detection of the blocked channel currents (by comparison). Ion Channel Modulators; K+ Channel Blockers. |
| Size |
5 x 0.2 mg |
| Applications |
n/a |
| Catalog # |
A-200 |
| Price |
$348 |
| Other Names |
n/a |
| Supplier Data Page |
Apamin from ALOMONE LABS |
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