C25-140 from CAYMAN CHEMICAL COMPANY
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| Product Name | C25-140 |
| Description | An inhibitor of the TRAF6-Ubc13 protein-protein interaction (IC50 = 2.6 µM); selectively inhibits the TRAF6-Ubc13 interaction over the interactions between Ubc13- OTUB1 and Ubc13-Uev1a; selectively inhibits TRAF6-dependent ubiquitination over a panel of various E3 ligase/E2 enzymes, but does inhibit cIAP1 and E1/E2 enzymes in cell-free assays at 30 µM; reduces IL-1β-induced activation of NF-κB in MEFs at 50 µM; topical application reduces scaling and erythema in a mouse model of imiquimod-induced psoriasis; decreases disease severity in a mouse model of collagen-induced arthritis from 6-14 mg/kg twice per day; reduces alveolar septal thickening, pulmonary edema, and inflammatory cell infiltration in BALF in a mouse model of lung injury induced by mechanical ventilation with high tidal volumes |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | C25140 TRAF6Ubc13 TRAF 6 Ubc 13 Ubc13OTUB1 Ubc13Uev1a cIAP 1 IL1β NFκB TLR 7 |
| Gene, Accession, CAS # | CAS: 1358099-18-9 |
| Catalog # | 39669-10 |
| Price | $273.00 |
| Order / More Info | C25-140 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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