MPI-0479605 from CAYMAN CHEMICAL COMPANY
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| Product Name | MPI-0479605 |
| Description | A potent inhibitor of MPS1 (IC50 = 1.8 nM); selective for MPS1 over a panel of 79 kinases at a concentration of 500 nM; induces time-dependent degradation of cyclin B and securin and decreases phosphorylation of BUBR1 resulting in failed cytokinesis in HeLa cells arrested by nocodazole; causes misalignment of chromosomes at the anaphase plate and aneuploidy in A549 cells and slows cell cycle progression of HCT116 and COLO 205 cells irrespective of p53 activity; reduces tumor volume in an HCT116 mouse colon cancer xenograft model in a dose-dependent manner, |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 1627922-40-0 MPI0479605 MPS-1 BUBR-1 HCT-116 COLO205 A-549 |
| Gene, Accession, CAS # | CAS: 1246529-32-7 |
| Catalog # | 22136-1 |
| Price | $57.00 |
| Order / More Info | MPI-0479605 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
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