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Product Name | Setmelanotide (trifluoroacetate salt) |
Description | A peptide agonist of MC4R; increases cAMP production in CHO-K1 cells expressing MC4R, MC1R, MC3R, and MC5R (EC50s = 0.27, 5.8, 5.3, and 1,600 nM, respectively, for the human receptors) but not in cells expressing MC2R (EC50 = >10 µM); inhibits food intake in MC3R, but not MC4R, knockout mice at 6.4 µmol/animal; reduces food intake and hepatosteatosis, induces weight loss, and decreases serum insulin, glucose, and leptin levels in a mouse model of diet-induced obesity at 300 nmol/kg per day |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | BIM-22493|N-acetyl-RCAHFRWC-NH2|RM-493 |
Gene, Accession, CAS # | n/a |
Catalog # | 35564-10 |
Price | $106.00 |
Order / More Info | Setmelanotide (trifluoroacetate salt) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |