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Product Name | ODM-201 |
Description | An androgen receptor antagonist (Ki = 11 nM); inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively); prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells; suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM); reduces tumor growth in a VCaP castrated mouse xenograft model at 50 mg/kg per day; inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model , |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | BAY 1841788 |
Gene, Accession, CAS # | CAS: 1297538-32-9 |
Catalog # | 25643-5 |
Price | $172.00 |
Order / More Info | ODM-201 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |