C188-9 from CAYMAN CHEMICAL COMPANY
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| Product Name | C188-9 |
| Description | A STAT3 inhibitor; binds to the STAT3 SH2 domain (Ki = 136 nM) and inhibits G-CSF-induced activation of STAT3 in patient-derived AML cells (IC50s = 8-18 µM); induces apoptosis in patient-derived AML cells (EC50s = 6-50 µM); reduces viability of HepG2, Huh7, and PLC/PRF/5 hepatoma cells (IC50s = 10.19, 11.27, and 11.83 µM, respectively); reduces hepatic Pten deletion-induced hepatic macro- and microsteatosis which reduces the development of hepatocellular carcinomas in mice at 100 mg/kg; increases muscle fiber size in a murine Lewis lung carcinoma model of cancer cachexia at 12.5 mg/kg |
| Size | 50 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | C1889 C 188-9 GCSF Hep G2 G 2 micro steatosis hepato cellular Huh 7 STAT 3 photo tyrosyl SH 2 |
| Gene, Accession, CAS # | CAS: 432001-19-9 |
| Catalog # | 30928-50 |
| Price | $510.00 |
| Order / More Info | C188-9 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY