LLY-283 from CAYMAN CHEMICAL COMPANY
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| Product Name | LLY-283 |
| Description | A PRMT5 inhibitor (IC50 = 22 nM); selective for PRMT5 over a panel of 32 methyltransferases at 1 µM; reduces symmetric demethylation of SmBB' in MCF-7 cells (IC50 = 25 nM); reduces proliferation of various cancer cell lines (IC50s = 3-30 nM); inhibits tumor growth in an A375 mouse xenograft model at 20 mg/kg; disrupts alternative splicing events in, and inhibits proliferation and self-renewal of, patient-derived glioblastoma stem cells; increases survival in an orthotopic PCX mouse model |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | LLY283 LM5179 LM-5179 PRMT-5MCF7 PRMT6 PRMT7 A-375 methyl transferase |
| Gene, Accession, CAS # | CAS: 2040291-27-6 |
| Catalog # | 21596-10 |
| Price | $243.00 |
| Order / More Info | LLY-283 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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