Seralutinib from CAYMAN CHEMICAL COMPANY
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| Product Name | Seralutinib |
| Description | A PDGFR, c-Kit, and CSF1R inhibitor; inhibits PDGF-BB-induced phosphorylation of ERK in H1703 cells, HPASMCs, and HLFs (IC50s = 74, 49, and 62 nM, respectively); inhibits stem cell factor-induced c-Kit autophosphorylation in HPAECs and M-CSF-induced CSF1R phosphorylation in human primary differentiated macrophages (IC50s = 7.8 and 14.4 nM, respectively); inhibits the proliferation of H1703 cells and PDGF-BB-induced HPASMCs and HLFs (IC50s = 32, 33, and 29 nM, respectively); prevents increases in pulmonary artery systolic pressure in a rat model of pulmonary arterial hypertension induced by monocrotaline pneumonectomy when administered via passive inhalation at 2.5 mg/kg |
| Size | 50 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | GB002|PK 10571 |
| Gene, Accession, CAS # | CAS: 1619931-27-9 |
| Catalog # | 37754-50 |
| Price | $728.00 |
| Order / More Info | Seralutinib from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY