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Product Name | TG6-10-1 |
Description | A potent EP2 receptor antagonist (Kb = 17.8 nM in C6 glioma cells overexpressing human EP2); 300-, 25-, and 10-fold selective for EP2 over other human EP3-4, FP and TP, and DP1 receptors, respectively; selective for EP2 over a panel of 40 enzymes, ion channels, receptors, and neurotransmitter transporters (IC50s >10 µM); increases survival, decreases weight loss, prevents induction of IL-1β, IL-6, TNF-α, and MCP-1/CCL2 mRNA, and inhibits neuronal cell death in the hippocampus in mouse and rat models of status epilepticus induced by pilocarpine and diisopropyl fluorophosphate, respectively |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | TG610-1 TG6-101 TG6101 EP-2 3 4 DP-2 IL1β IL6 TNFα MCP1 CCL-2 EP3 EP4 DP-1 IL1B TNFa |
Gene, Accession, CAS # | CAS: 1415716-58-3 |
Catalog # | 23444-5 |
Price | $151.00 |
Order / More Info | TG6-10-1 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |