NE52-QQ57 from CAYMAN CHEMICAL COMPANY
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| Product Name | NE52-QQ57 |
| Description | A GPR4 antagonist (IC50 = 0.04 µM); selective for GPR4 over hERG and histamine H3 receptor (IC50s = 19 and >30 µM, respectively); decreases the IL-33-induced increases in IL-17, IFN-γ, TNF-α, NF-κB, MMP-2, MMP-9, and COX-2 levels in, and PGE2 secretion by, HMC-1 mast cells at 2 µM; reduces IL-33-induced increases in mitochondrial ROS in the same cells; increases colon length and reduces fecal blood levels and incidence of diarrhea, lymph node volumes and spleen weight, as well as reduces distal and mid colon inflammation and leukocyte infiltration levels, in a mouse model of DSS-induced ulcerative colitis at 30 mg/kg twice per day; increases the mechanical paw withdrawal threshold in a rat model of CFA-induced inflammatory pain at 3, 10, or 30 mg/kg |
| Size | 50 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | NE52QQ57 GRP 5 IL17 IFNγ TNFα NFκB MMP2 MMP9 COX2 IL33 HMC1 |
| Gene, Accession, CAS # | CAS: 1401728-56-0 |
| Catalog # | 40647-50 |
| Price | $688.00 |
| Order / More Info | NE52-QQ57 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY