BI-882370 from CAYMAN CHEMICAL COMPANY
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| Product Name | BI-882370 |
| Description | A RAF inhibitor (IC50s = 0.8, 0.8, and 0.6 nM for B-RAFV600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively); selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC50s = 49, 415, 485, 750, 715, and 1,220 nM, respectively); inhibits proliferation of human B-RAF-mutant melanoma cells at 1-10 nM; reduces tumor growth in multiple B-RAF-mutant melanoma and colorectal carcinoma mouse xenograft models at 25 mg/kg twice per day |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | BI882370 BRAFV600E B-RAF-V600E RAFV600E CRAF A-375 |
| Gene, Accession, CAS # | CAS: 1392429-79-6 |
| Catalog # | 24273-5 |
| Price | $139.00 |
| Order / More Info | BI-882370 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY