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Product Name | Xaliproden (hydrochloride) |
Description | A 5-HT1A agonist (IC50 = 4.3 nM in a radioligand binding assay); selective for 5-HT1A over 5-HT2 and α1-adrenergic receptors (IC50s = 697 and 630 nM, respectively), as well as a panel of 13 additional neurotransmitter receptors and ion channels (IC50s = ≥10 µM for all) but also binds σ receptors (IC50 = 73 nM); increases NGF-induced neurite outgrowth and α-actinin levels in PC12 cells at 250 nM; decreases hippocampal neuronal damage and reduces impairments in sensorimotor function in rat models of transient global ischemia induced by 4-VO and sciatic nerve crush injury, respectively, at 10 mg/kg per day; inhibits CNS mononuclear cell infiltration and increases in cerebrospinal fluid IgG levels in a rat model of EAE induced by myelin basic protein at 10 mg/kg per day |
Size | 50 mg |
Concentration | n/a |
Applications | n/a |
Other Names | SR 57746A |
Gene, Accession, CAS # | CAS: 90494-79-4 |
Catalog # | 31468-50 |
Price | $517.00 |
Order / More Info | Xaliproden (hydrochloride) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |