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Product Name | TH-302 |
Description | A hypoxia-activated prodrug and DNA alkylating agent with anticancer activity; selectively cytotoxic to H460 human NSCLC cells grown under hypoxic over normoxic conditions (IC50s = 0.019 and 5.1 µM, respectively); reduces survival of H460 and HT-29 cells in a clonogenic assay (IC50s = 0.2 and 0.2 µM, respectively); inhibits primary tumor growth by 41% in an MIA PaCa-2-RFP mouse orthotopic xenograft model at 33 mg/kg per day; inhibits tumor growth in the Calu-6 NSCLC, H82 small cell lung, A375 melanoma, PC-3 prostate, and BxPC-3 pancreatic cancer mouse xenograft models at 50 mg/kg |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | Evofosfamide |
Gene, Accession, CAS # | CAS: 918633-87-1 |
Catalog # | 22195-25 |
Price | $590.00 |
Order / More Info | TH-302 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |