EDO-S101 from CAYMAN CHEMICAL COMPANY
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| Product Name | EDO-S101 |
| Description | An HDAC inhibitor and DNA alkylating agent; inhibits class I and II HDACs (IC50s = 9-107 nM for HDAC1-3, 6, 8, and 10); inhibits HDAC activity in rat PBMCs ex vivo by 90% after a single dose of 10 mg/kg; induces formation of DNA crosslinks and double-strand breaks in HL-60 cells; reduces growth of MM cell lines irrespective of p53 mutational status or established resistance to DNA alkylating agents (IC50s = 1.6-4.8 µM); induces MM cell death ex vivo in bone marrow samples isolated from patients with early- and late-stage MM; reduces tumor growth and prolongs survival in an MM1S end-stage mouse xenograft model when administered at a dose of 60 mg/kg per week; prolongs survival in a multidrug resistant Vk12653 mouse transplant model of refractory MM, |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | EDOS101 EDO-S-101 HDAC-1 2 HL60 MM-1S Vk-12653 HDAC1 HDAC2 HDAC3 HDAC6 HDAC8 HDAC10 |
| Gene, Accession, CAS # | CAS: 1236199-60-2 |
| Catalog # | 23328-25 |
| Price | $1,184.00 |
| Order / More Info | EDO-S101 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY