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Product Name | MRK-560 |
Description | A potent inhibitor of γ-secretase (IC50 = 0.65 nM); reduces diethanolamine-soluble Aβ40 levels in APP-YAC transgenic mouse brain from 1-10 mg/kg; reduces brain and cerebrospinal fluid Aβ40 levels in rats (ED50s = 6 and 10 mg/kg, respectively); decreases brain-soluble Aβ40 and Aβ42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer's disease |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | MRK560 γsecretase amyloidβ APPYAC Aβ 40 42 Tg 2576 |
Gene, Accession, CAS # | CAS: 677772-84-8 |
Catalog # | 27599-5 |
Price | $363.00 |
Order / More Info | MRK-560 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |