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Product Name | GS-444217 |
Description | An AKS1 inhibitor (IC50 = 2.87 nM); selective for ASK1 over 442 additional kinases at 1 µM; inhibits phosphorylation of the ASK1 substrates MKK3, MKK6, and MKK4, as well as p38 MAPK and JNK in HEK293T cells expressing human ASK1 from 0.001-10 µM; reduces renal fibrosis and proteinuria in a db/db eNOS-/- mouse model of DKD at 0.3% w/w |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | Apoptosis Signal-regulating Kinase 1 Inhibitor 1|Apoptosis Signal-regulating Kinase 1-IN-1|ASK1 Inhibitor 1|ASK1-IN-1 |
Gene, Accession, CAS # | CAS: 1262041-49-5 |
Catalog # | 40757-10 |
Price | $126.00 |
Order / More Info | GS-444217 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |