2-APB from TOCRIS BIOSCIENCE

TOCRIS BIOSCIENCE

TOCRIS BIOSCIENCE

Tocris House, IO Centre

Moorend Farm Avenue

Avonmouth, Bristol, BS11 0QL UNITED KINGDOM

Phone: + 44 (0)117 916 3333

Fax: + 44 (0)117 916 3344

Email: customerservice@tocris.co.uk

Website: http://www.tocris.com

U.S.A. OFFICE: Tocris Bioscience
16144 Westwoods Business Park
Ellisville, Missouri 63021 USA

Telephone: (800) 421-3701/(636) 207-7651
Fax: (800) 483-1993/(636) 207-7683
E-mail: customerservice@tocrisusa.com

2-APB from TOCRIS BIOSCIENCE

Name	2-APB
Description	Minimum Purity: > 98%. A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 µM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 µM) and inhibits it at higher concentrations (up to 50 µM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.
Size	50mg
Applications	n/a
Catalog #	1224
Price	€195
Other Names	CAS No. [524-95-8]
Supplier Data Page	2-APB from TOCRIS BIOSCIENCE

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