IGF1R beta Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-IGF1R beta antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | IGF1R beta |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | ascites |
| Size | 100 µl |
| Concentration | n/a |
| Applications | ELISA, WB, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines.Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs.The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation.Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation.Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151.Full kinase activation requires the triple tyrosine phosphorylation. |
| Immunogen | Purified recombinant fragment of IGF1R-Beta (AA: 1101-1367) expressed in E. coli. |
| Other Names | IGF1R, IGF1R-Beta, IGF1R, IGF1R, IGF1R, IGF1R, IGF1R-Beta, IGF1R-Beta, IGF1R-Beta, IGF1R-Beta |
| Gene, Accession # | IGF1R, Gene ID: 3480, UniProt: P08069 |
| Catalog # | abx016028 |
| Price | please inquire |
| Order / More Info | IGF1R beta Antibody from ABBEXA LTD |
| Product Specific References | n/a |
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950
Customer Service: info@abbexa.com
Technical Support: support@abbexa.com
Orders: orders@abbexa.com
https://www.abbexa.com
U.S. Office
118 Eldridge Rd, Suite C,
Sugar Land, TX 77478 USA
Telephone: +1 832 327 7413
Netherlands Office
Abbexa BV
Wattstraat 54 2723 RD,
Zoetermeer,Netherlands
Telephone: +44 (0) 1223 755950
Profile of ABBEXA LTD
Return to Antibodies