Mothers Against Decapentaplegic Homolog 2 Phospho-Thr220 (SMAD2 pT220) Antibody from ABBEXA LTD
Search, find, compare suppliers for anti-Mothers Against Decapentaplegic Homolog 2 Phospho-Thr220 (SMAD2 pT220) antibody, protein, ELISA kits.
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| Antigenic Specificity | Mothers Against Decapentaplegic Homolog 2 Phospho-Thr220 (SMAD2 pT220) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 80 µl, 400 µl |
| Concentration | n/a |
| Applications | ELISA, WB, IF/ICC, DB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | SMAD2 is a 58 kDa member of a family of proteins involved in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor-regulated Smad?s, activin/TGF?receptor-regulated (Smad2 and 3) or BMP receptor regulated (Smad1, 5, and 8) ; the common partner, (Smad4) that functions via its interaction to the various Smad?s; and the inhibitory Smad?s, (Smad6 and Smad7). Smad2 consists of two highly conserved domains, the N terminal Mad homology (MH1) and the C-terminal Mad homology 2 (MH2) domains. The MH1 domain binds DNA and regulates nuclear import and transcription while the MH2 domain conserved among all the Smad?s regulates Smad2 oligomerization and binding to cytoplasmic adaptors and transcription factors. Activated Smad2 associates with Smad4 and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. This translocation of Smad2 (as well as Smad3) into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin binding region of the MH1 domain by extracellular signal regulated kinase 1 (ERK 1) enhances Smad2 transcriptional activity, which is negatively regulated by calmodulin. The regulation of Smad2 phosphorylation on threonine 8 by ERK 1 and calmodulin is critical for Smad2 mediated signaling. |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T220 of human SMAD2. |
| Other Names | JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, MGC22139, MGC34440, Mad-related protein 2, Mothers DPP homolog 2, Mothers decapentaplegic homolog 2, Smad 2, MAD homolog 2, SMAD family member 2, Smad2, SMAD3, MADH3, Mothers decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, hSMAD3, V18, Mothers against, JV18, JV18, JV18, JV18, MADH2, MADH2, MADH2, MADH2, MADR2, MADR2, MADR2, MADR2, JV18-1, JV18-1, JV18-1, JV18-1, hMAD-2, hMAD-2, hMAD-2, hMAD-2, hSMAD2, hSMAD2, hSMAD2, hSMAD2, MGC22139, MGC22139, MGC22139, MGC22139, MGC34440, MGC34440, MGC34440, MGC34440, Mad-related protein 2, Mad-related protein 2, Mad-related protein 2, Mad-related protein 2, Mothers DPP homolog 2, Mothers DPP homolog 2, Mothers DPP homolog 2, Mothers DPP homolog 2, Mothers decapentaplegic homolog 2, Mothers decapentaplegic homolog 2, Mothers decapentaplegic homolog 2, Mothers decapentaplegic homolog 2, Smad 2, Smad 2, Smad 2, Smad 2, MAD homolog 2, MAD homolog 2, MAD homolog 2, MAD homolog 2, SMAD family member 2, SMAD family member 2, SMAD family member 2, SMAD family member 2, Smad2, Smad2, Smad2, Smad2, SMAD3, SMAD3, SMAD3, SMAD3, MADH3, MADH3, MADH3, MADH3, Mothers decapentaplegic homolog 3, Mothers decapentaplegic homolog 3, Mothers decapentaplegic homolog 3, Mothers decapentaplegic homolog 3, MAD homolog 3, MAD homolog 3, MAD homolog 3, MAD homolog 3, Mad3, Mad3, Mad3, Mad3, Mothers DPP homolog 3, Mothers DPP homolog 3, Mothers DPP homolog 3, Mothers DPP homolog 3, hMAD-3, hMAD-3, hMAD-3, hMAD-3, JV15-2, JV15-2, JV15-2, JV15-2, SMAD family member 3, SMAD family member 3, SMAD family member 3, SMAD family member 3, SMAD 3, SMAD 3, SMAD 3, SMAD 3, hSMAD3, hSMAD3, hSMAD3, hSMAD3, V18, V18, V18, V18, Mothers against, Mothers, Mothers, Mothers against |
| Gene, Accession # | NCBI Accession: NP_001003652.1, NP_005892.1, UniProt: Q15796 |
| Catalog # | abx032070 |
| Price | please inquire |
| Order / More Info | Mothers Against Decapentaplegic Homolog 2 Phospho-Thr220 (SMAD2 pT220) Antibody from ABBEXA LTD |
| Product Specific References | n/a |
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