CHK1 (pS317) Antibody from ABBEXA LTD

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Antigenic SpecificityCHK1 (pS317)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatpeptide affinity purified
Size80 µl, 400 µl
Concentrationn/a
ApplicationsELISA, WB, IHC, DB
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DescriptionCheckpoint pathways control the order and timing of cell cycle transitions and ensure that critical events, such as DNA replication and chromosome segregation, are completed with high fidelity. The S. pombe Chk1 gene encodes a protein kinase that is required for the DNA damage checkpoint. Antibodies against CHK1 recognized a 54-kD protein on immunoblots of mammalian cell extracts. However, CHK1 is modified in response to DNA damage. In vitro, CHK1 directly phosphorylated a regulator of CDC2 tyrosine phosphorylation, CDC25C. In response to DNA damage, CHK1 phosphorylates and inhibits CDC25C, thus preventing activation of the CDC2-cyclin B complex and mitotic entry. CHK1 directly phosphorylates CDC25A during an unperturbed cell cycle, and that phosphorylation of CDC25A by CHK1 is required for cells to delay cell cycle progression in response to double-strand DNA breaks.
ImmunogenKLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S317 of human CHK1.
Other NamesCheckpoint, S. pombe, homolog of, 1, CHEK1, CHK1, CHK1 checkpoint homolog (S. pombe), Serine/threonine-protein kinase Chk1, kinase Chk1, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Checkpoint kinase-1, Checkpoint, Checkpoint, Checkpoint, Checkpoint, S. pombe, S. pombe, S. pombe, S. pombe, homolog of, homolog of, homolog of, homolog of, 1, 1, 1, 1, CHEK1, CHEK1, CHEK1, CHEK1, CHK1, CHK1, CHK1, CHK1, CHK1 checkpoint homolog (S. pombe), CHK1 checkpoint homolog (S. pombe), CHK1 checkpoint homolog (S. pombe), CHK1 checkpoint homolog (S. pombe), Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk1, kinase Chk1, kinase Chk1, kinase Chk1, kinase Chk1, CHK1 checkpoint homolog, CHK1 checkpoint homolog, CHK1 checkpoint homolog, CHK1 checkpoint homolog, Cell cycle checkpoint kinase, Cell cycle checkpoint kinase, Cell cycle checkpoint kinase, Cell cycle checkpoint kinase, Checkpoint kinase-1, Checkpoint kinase-1, Checkpoint kinase-1, Checkpoint kinase-1
Gene, Accession #UniProt: O14757
Catalog #abx031852
Priceplease inquire
Order / More InfoCHK1 (pS317) Antibody from ABBEXA LTD
Product Specific Referencesn/a
ABBEXA LTD
ABBEXA LTD
ABBEXA LTD
181 Cambridge Science Park
Cambridge, CB4 0GJ UK
P: +44 (0) 1223 755950

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