CTLA4 Antibody from ANTIBODIES-ONLINE GmbH

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Antigenic SpecificityCTLA4
CloneBNI3
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2a
Formatallophycocyanin (APC) conjugate
Size100 tests
Concentrationn/a
ApplicationsFlow Cytometry, Immunocytochemistry, Immunohistochemistry (Formalin-fixed Sections), Immunoprecipitation
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DescriptionProduct Characteristics: CD152 / CTLA-4 is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 / CTLA-4 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy.Target Information: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].
ImmunogenHuman CD152-IgG heavy chain fusion protein
Other NamesCD|CD152|CELIAC3|CTLA-4|GRD4|GSE|IDDM12|CD152 isoform|celiac disease 3|cytotoxic T lymphocyte associated antigen 4 short spliced form|cytotoxic T-lymphocyte antigen 4|cytotoxic T-lymphocyte protein 4|cytotoxic T-lymphocyte-associated antigen 4|cytotoxic T-lymphocyte-associated serine esterase-4|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4|cytotoxic T-lymphocyte associated protein 4|CTLA4|Cytotoxic T-Lymphocyte-Associated Protein 4|Ly-56|CD152 antigen|sCTLA4|soluble form|transmembrane form|cytotoxic T-lymphocyte-associated protein 4 precursor|CD152 protein|cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM|cytotoxic T lymphocyte-associated protein 4|costimulatory molecule B7 receptor CD152|costimulatory molecule B7 receptor|cytotoxic T lymphocyte-associated antigen 4
Gene, Accession #Gene ID: 1493
Catalog #ABIN5711614
Price$497.45
Order / More InfoCTLA4 Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155

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