CTLA4 Antibody from ANTIBODIES-ONLINE GmbH
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| Antigenic Specificity | CTLA4 |
| Clone | BNI3 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests |
| Concentration | n/a |
| Applications | Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Formalin-fixed Sections), Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Characteristics: CD152 / CTLA-4 is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 / CTLA-4 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy.Target Information: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]. |
| Immunogen | Human CD152-IgG heavy chain fusion protein |
| Other Names | CD|CD152|CELIAC3|CTLA-4|GRD4|GSE|IDDM12|CD152 isoform|celiac disease 3|cytotoxic T lymphocyte associated antigen 4 short spliced form|cytotoxic T-lymphocyte antigen 4|cytotoxic T-lymphocyte protein 4|cytotoxic T-lymphocyte-associated antigen 4|cytotoxic T-lymphocyte-associated serine esterase-4|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4|cytotoxic T-lymphocyte associated protein 4|CTLA4|Cytotoxic T-Lymphocyte-Associated Protein 4|Ly-56|CD152 antigen|sCTLA4|soluble form|transmembrane form|cytotoxic T-lymphocyte-associated protein 4 precursor|CD152 protein|cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM|cytotoxic T lymphocyte-associated protein 4|costimulatory molecule B7 receptor CD152|costimulatory molecule B7 receptor|cytotoxic T lymphocyte-associated antigen 4 |
| Gene, Accession # | Gene ID: 1493 |
| Catalog # | ABIN5711614 |
| Price | $497.45 |
| Order / More Info | CTLA4 Antibody from ANTIBODIES-ONLINE GmbH |
| Product Specific References | n/a |
ANTIBODIES-ONLINE GmbH
ANTIBODIES-ONLINE GmbH
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
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