Search, find, compare suppliers for anti-TRPV4 antibody, protein, ELISA kits.

Antigenic SpecificityTRPV4
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Size100 µL
ApplicationsImmunohistochemistry, Western Blotting
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DescriptionProduct Characteristics: TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure.Function: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.Subunit: Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES.Subcellular location: Membrane, Multi-pass membrane protein.Tissue specificity: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 3 ANK repeats. Also known as: Transient receptor potential cation channel subfamily V member 4, TrpV4, osm-9-like TRP channel 4, OTRPC4, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, Vanilloid receptor-related osmotically-activated channel, VR-OAC, Transient receptor potential protein 12, TRP12, Trp12, VRL-2, VROAC, OTRPC4, VR-OAC, MGC150050, 0610033B08Rik, Trp12, Vrl2, Vroac.Target Information: This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010].
ImmunogenA synthetic peptide from the 1t cytoplasmic loop of human TRPV4 conjugated to blue carrier protein was used as the antigen.
Other NamesVR-OAC|transient receptor potential cation channel subfamily V member 4|vanilloid receptor-related osmotically activated channel protein|TRPV4|Transient Receptor Potential Cation Channel, Subfamily V, Member 4|0610033B08Rik|OTRPC4|Trp12|VRL-2|VROAC|osm-9-like TRP channel 4|osmosensitive transient receptor potential channel 4|transient receptor potential protein 12|vanilloid receptor-like channel 2|vanilloid receptor-like protein 2|vanilloid receptor-related osmotically-activated channel|CMT2C|HMSN2C|SMAL|SPSMA|SSQTL1|VRL2|OSM9-like transient receptor potential channel 4|vanilloid receptor-related osmotically activated channel|transient receptor potential cation channel|subfamily 5|member 4|vanilloid receptor-related osmotically activated channel (Vroac)|wu:fp52e02|subfamily V|transient receptor potential cation channel subfamily V member 4-like
Gene, Accession #Gene ID: 59341, 63873, 66026
Catalog #ABIN350026
Order / More InfoTRPV4 Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155
Technical Support:

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