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Antigenic SpecificityMYD88
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Size200 µL
ApplicationsImmunohistochemistry, Western Blotting
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DescriptionProduct Characteristics: Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 AAs known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. MyD88 was originally isolated as a myeloid differentiation primary response gene that is rapidly induced upon IL-6 stimulated differentiation of M1 myeloleukemic cells into macrophages. It contains an amino-terminal death domain separated from a carboxyl-terminal TIR domain and functions as an adaptor in TLR/IL-1 receptor signaling. The death domain of MyD88 mediates interactions with the IRAK complex triggering a signaling cascade that includes the activation of NF-kappaB.Synonyms: MYD88DTarget Information: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
ImmunogenRecombinant protein of human MyD88
Other NamesMYD88D|myeloid differentiation primary response gene (88)|myeloid differentiation primary response protein MyD88|myeloid differentiation primary response 88|MYD88|MGC84928|XMyD88|Toll/IL-1 receptor binding protein MyD88-B|myeloid differentiation primary response protein MyD88-B|myeloid differentiation primary response 88 S homeolog|myd88.S|myeloid differentiation primary response gene 88|CG2078|DMMYD88|DmelCG2078|EP(2)2535|Kra|LD20892|Myd88F|dMyD88|CG2078-PA|CG2078-PB|Myd88-PA|Myd88-PB|krapfen|CG2078 gene product from transcript CG2078-RB|zgc:103541|myeloid differentiation primary response factor 88|zMyD88|GB12344|myeloid differentiation primary response protein MyD88-A|LOC413194|myeloid differentiation factor 88|myeloid differentiation primary response protein 88|NV10640|LOC100118553|myeloid differentiation response protein 88|LOC575153
Gene, Accession #Gene ID: 4615, 17874, 301059
Catalog #ABIN3021215
Order / More InfoMYD88 Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155
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