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Antigenic Specificity | TNFRSF1B |
Clone | MR2-1 |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | biotin conjugate |
Size | 50 µg |
Concentration | n/a |
Applications | Flow Cytometry, Immunoassay, Immunohistochemistry (Frozen Sections), Western Blotting |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody reacts with the extra-cellular part of the TNF-RII. It also reacts with the soluble receptor. TNF-RII is present on most cell types and is considered to play a prominent role in cell stimulation by TNF- alpha. TNF-RII molecule is shown to be responsible for stimulation of activated T-lymphocytes by TNF- alpha. The antibody cross reacts with rhesus and cynomolgus natural TNF-RII. Target Information: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]. |
Immunogen | n/a |
Other Names | CD120b|TBPII|TNF-R-II|TNF-R75|TNFBR|TNFR1B|TNFR2|TNFR80|p75|p75TNFR|TNF-R2|TNF-RII|p75 TNF receptor|p80 TNF-alpha receptor|soluble TNFR1B variant 1|tumor necrosis factor beta receptor|tumor necrosis factor binding protein 2|tumor necrosis factor receptor 2|tumor necrosis factor receptor superfamily member 1B|tumor necrosis factor receptor type II|TNF receptor superfamily member 1B|TNFRSF1B|Tumor Necrosis Factor Receptor Superfamily, Member 1B|TNF-RIITNFRSF1B|TNFR-II|tumor necrosis factor receptor-II|tumor necrosis factor receptor superfamily|member 1B|TNF-alphaR2|TNFRII|TNFalpha-R2|Tnfr-1|TNF receptor beta chain|p75 TNFR|rank|zgc:163064 |
Gene, Accession # | Gene ID: 7133 |
Catalog # | ABIN2191871 |
Price | $508 |
Order / More Info | TNFRSF1B Antibody from ANTIBODIES-ONLINE GmbH |
Product Specific References | n/a |