Search, find, compare suppliers for anti-ROBO1 antibody, protein, ELISA kits.

Antigenic SpecificityROBO1
Host SpeciesRabbit
Reactive Specieshuman
Size100 µg
Concentration1.0 mg/mL
ApplicationsELISA, Immunohistochemistry, Immunoprecipitation, Western Blotting
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DescriptionProduct Characteristics: ROBO-1 (also called Roundabout homolog 1 precursor and Deleted in U twenty twenty (DUTT)) functions as a receptor for SLIT1 and SLIT2. The SLIT proteins are thought to act as a molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. ROBO-1 may also be required for lung development. ROBO-1 is a type I membrane protein. ROBO-1 is a widely expressed protein with the exception of the kidney. Defects in ROBO1 may be a cause of breast and lung cancer. ROBO-1 maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line. Multiple splice variants have been identified for this protein.Synonyms: ROBO-1, Roundabout homolog 1 precursor, Deleted in U twenty twenty (DUTT)Target Information: Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
ImmunogenThis affinity-purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1632-1644 of Human ROBO-1.
Other NamesDUTT1|SAX3|deleted in U twenty twenty|roundabout homolog 1|roundabout guidance receptor 1|ROBO1|Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila)|AW494633|AW742721|Gm310|roundabout (axon guidance receptor|Drosophila) homolog 1|Roundabout1 protein|roundabout|axon guidance receptor|homolog 1 (Drosophila)|roundabout-1|roundabout guidance receptor 1 L homeolog|robo1.L|roundabout 1|MGC122264|homolog 1|roundabout homolog 1-like
Gene, Accession #Gene ID: 6091
Catalog #ABIN129621
Order / More InfoROBO1 Antibody from ANTIBODIES-ONLINE GmbH
Product Specific Referencesn/a
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155
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