s100b Antibody from ANTIBODIES-ONLINE GmbH

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Antigenic Specificitys100b
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Size200 µL
ApplicationsImmunohistochemistry, Western Blotting
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DescriptionProduct Characteristics: Despite their relatively small size (8-12 kDa) and uncomplicated architecture, S100 proteins regulate a variety of cellular processes such as cell growth and motility, cell cycle progression, transcription, and differentiation. To date, 25 members have been identified, including S100A1-S100A18, trichohyalin, filaggrin, repetin, S100P, and S100Z, making it the largest group in the EF-hand, calcium-binding protein family. Interestingly, 14 S100 genes are clustered on human chromosome 1q21, a region of genomic instability. Research studies have demonstrated that significant correlation exists between aberrant S100 protein expression and cancer progression. S100 proteins primarily mediate immune responses in various tissue types but are also involved in neuronal development.Each S100 monomer bears two EF-hand motifs and can bind up to two molecules of calcium (or other divalent cation in some instances). Structural evidence shows that S100 proteins form antiparallel homo- or heterodimers that coordinate binding partner proximity in a calcium-dependent (and sometimes calcium-independent) manner. Although structurally and functionally similar, individual members show restricted tissue distribution, are localized in specific cellular compartments, and display unique protein binding partners, which suggests that each plays a specific role in various signaling pathways. In addition to an intracellular role, some S100 proteins have been shown to act as receptors for extracellular ligands or are secreted and exhibit cytokine-like activities. S100B is abundantly expressed in astrocytes and is commonly used as an astrocytic marker in studies of the mammalian CNS. S100B is also expressed in immature and mature myelinating oligodendrocytes that are chondroitin sulfate proteoglycan (NG2)-positive.Synonyms: S100B, NEF, S100, S100betaTarget Information: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21, however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008].
ImmunogenRecombinant Protein of human pSer100 B
Other NamesNEF|S100|S100-B|S100beta|S-100 calcium-binding protein|beta chain|S-100 protein subunit beta|S100 calcium-binding protein|beta (neural)|protein S100-B|S100 calcium binding protein B|S100B|S100P|S-100 protein beta chain|S100 calcium-binding protein B|S100 calcium-binding protein beta (neural)|S100 protein|beta polypeptide|neural|AI850290|Bpb|S100 protein, beta polypeptide, neural|S100 calcium binding protein|beta|S-100 calcium-binding protein beta subunit|si:dkey-110p14.2|wu:fq18b10|zgc:92776|S100 calcium binding protein, beta (neural)
Gene, Accession #Gene ID: 6285, 20203, 25742
Catalog #ABIN3021049
Order / More Infos100b Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 27624805, 27624805, 27624805, 27624805, 27332707, 27332707, 27332707, 27332707
Schloss-Rahe-Str. 15
52072 Aachen GERMANY
P: +49 (0)241 95 163 153
F: +49 (0)241 95 163 155

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