Tau, 189-195 Antibody from BIOLEGEND

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Antigenic SpecificityTau, 189-195
Clone39E10
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1, κ
Formatpurified, azide-free
Size100 µL
Concentrationn/a
ApplicationsWestern Blot (WB)
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DescriptionPurified (azide-free) anti-Tau, 189-195.

Tau protein promotes microtubule assembly and stability. Tau is abundant in neurons of the central nervous system, and is expressed at low levels in astrocytes and oligodendrocytes. Abnormal hyper-phosphorylation, aggregation, and toxic gain of function of tau is associated with several neurological disorders, including Alzheimer's disease (AD). The major building block of neurofibrillary lesions in AD brains consists of paired helical filaments (PHFs) of abnormally hyperphosphorylated tau. Six isoforms of tau are generated by alternative splicing of the MAPT gene. These isoforms are distinguished by the number of tubulin binding domains, 3 (3R) or 4 (4R), in the C-terminal of the protein and by one (1N), two (2N), or no (0N) inserts in the N-terminal domain.  Tau isoforms are differentially expressed during development.

ImmunogenThis monoclonal antibody was raised against full-length human tau.
Other NamesMicrotubule-associated protein tau, PHF-tau, Paired Helical Filament tau
Gene, Accession #Gene ID: 4137
Catalog #814301
Price$234
Order / More InfoTau, 189-195 Antibody from BIOLEGEND
Product Specific ReferencesPubMed: 28606756
BIOLEGEND
BIOLEGEND
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