Apo E4 Antibody from BIOLEGEND

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Antigenic SpecificityApo E4
Clone5B5/ApoE4
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1, κ
Formatpurified, azide-free
Size100 µL
Concentrationn/a
ApplicationsIHC-P
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DescriptionPurified (azide-free) anti-Apo E4.

Apolipoprotein E (ApoE) belongs to a class of apolipoproteins that binds to lipids to form lipoproteins. ApoE is produced by the liver and macrophages in peripheral tissues where it regulates cholesterol metabolism. In the central nervous system, ApoE is primarily produced by astrocytes and plays an important role in transporting cholesterol to neurons via ApoE receptors. ApoE has three major isoforms corresponding to three alleles (ApoE2, ApoE3 and ApoE4) that differ from each other by only one or two amino acids at positions 112 and 158. ApoE4 is one of the largest known genetic risk factors for late-onset Alzheimer?s disease. Further, ApoE4 has been implicated in several other diseases such as atherosclerosis, impaired cognitive function and multiple sclerosis.

ImmunogenThis monoclonal antibody was raised against a peptide sequence derived from the human APO E4 protein.
Other NamesAPO-E, Apolipoprotein E, Apolipoprotein E4, ApoE
Gene, Accession #Gene ID: 348
Catalog #811601
Price$234
Order / More InfoApo E4 Antibody from BIOLEGEND
Product Specific ReferencesPubMed: 33097708
BIOLEGEND
BIOLEGEND
BIOLEGEND
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