PICK1 Antibody from BIOLEGEND

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Antigenic SpecificityPICK1
CloneL20/8
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
IsotypeIgG2a
Formatperoxidase (HRP) conjugate
Size25 µg
Concentrationn/a
ApplicationsWestern Blot (WB)
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DescriptionHRP anti-PICK1.

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. (Uniprot)

ImmunogenThis monoclonal antibody was raised against a fusion protein corresponding to amino acids 10-130 of rat PICK1 protein.
Other NamesPRKCA-binding protein, protein interacting with C kinase 1, protein kinase C-alpha-binding protein, protein that interacts with C kinase 1, protein kinase C, alpha binding protein, PRKCABP
Gene, Accession #Gene ID: 84591
Catalog #830903
Price$100
Order / More InfoPICK1 Antibody from BIOLEGEND
Product Specific ReferencesPubMed: 32304633
BIOLEGEND
BIOLEGEND
BIOLEGEND
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