PARP Antibody from BIOVISION, INC.

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Antigenic SpecificityPARP
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formataffinity purified
Size30 µg
Concentration0.2 mg/ml
ApplicationsWestern blot. RUO
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DescriptionRabbit anti-PARP Antibody. Lot# 50802. PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP's N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.
ImmunogenSynthetic peptide corresponding to caspase cleavage site in human PARP
Other NamesPARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1
Gene, Accession #Gene ID: 142, Accession: NP 001609
Catalog #3002-30T
Price$89
Order / More InfoPARP Antibody from BIOVISION, INC.
Product Specific Referencesn/a
BIOVISION, INC.
BIOVISION, INC.
BIOVISION, INC.
155 S. Milpitas Boulevard
Milpitas CA 95035
P: 408-493-1800
P: 800-891-9699
F: 408-493-1801

support@biovision.com

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