14-3-3 Antibody from BON OPUS BIOSCIENCES LLC

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Antigenic Specificity14-3-3
Clonemonoclonal
Host SpeciesRecombinant Rabbit
Reactive Specieshuman, mouse, rat
IsotypeIgG
FormatProtein A purified
Size100 µl
Concentrationn/a
ApplicationsWB, IHC
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Description14-3-3 Recombinant Rabbit monoclonal Antibody IgG. The 14-3-3 family of proteins are important regulatory molecules ubiquitiously expressed in all eukarryotic cells which bind to numerous signaling proteins in various pathways driving critical cellular pathways of apoptosis, differentiation and cell cycle. 14-3-3 theta specifically has also been shown to play an important regulatory role in the TLR2 signaling pathways as a negative regulator of TLR2 ligand Pam3CySk4 induced NF-kB activation. 14-3-3 theta has previously been shown to interact with TLR4 ligand and MyD88 dependent phosphorylated PkC epsilon. 14-3-3 theta in the TLR4 signaling pathway is a positive regulator controlling release of IRF3 indcuded pro-inflammatory cytokines RANTES and IP-10. Currently identified by mass spec as part of the TLR2 signaling complex and taken along with TLR4 data, a 14-3-3 theta antibody can be used to examine the different regulatory functions of 14-3-3 theta for different TLRs through its interaction with common or unique TLR signaling adaptor molecules in addition to MyD88 or PkC epsilon such as TRAM or TRIF allowing further clarification of TLR specific pathway regulation.(ET1701-2)
ImmunogenRecombinant protein
Other Names14-3-3 protein beta/alpha, Protein 1054, Protein kinase C inhibitor protein 1, 14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1
Gene, Accession #UniProt: P31946 (Human) P63104 (Human) P63101 (Mouse) Q9CQV8 (Mouse) P35213 (Rat) P63102 (Rat)
Catalog #BA111916
Price$279
Order / More Info14-3-3 Antibody from BON OPUS BIOSCIENCES LLC
Product Specific Referencesn/a
BON OPUS BIOSCIENCES LLC
BON OPUS BIOSCIENCES LLC
BON OPUS BIOSCIENCES LLC
150 Essex St
Millburn NJ 07041
P: (800) 943-6396
F: (888) 253-6691

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