SQSTM1/p62 Antibody from BOSTER BIO

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Antigenic SpecificitySQSTM1/p62
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat (predicted: hamster)
Formatimmunogen affinity purified
Size100ug (sample available)
ApplicationsIHC, ICC, WB
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DescriptionRabbit IgG polyclonal antibody for Sequestosome-1(SQSTM1) detection. Tested with WB, IHC-P, ICC in Human;Mouse;Rat. No cross reactivity with other proteins. SQSTM1(Sequestosome-1), also known as Ubiquitin-Binding Protein P62 or P62, is a protein that in humans is encoded by the SQSTM1 gene. The Src homology type 2(SH2) domain is a highly conserved motif of about 100 amino acids which mediates protein-protein interactions by binding to phosphotyrosine.p56-lck, a T-cell-specific src family tyrosine kinase with an SH2 domain, is involved in T-cell signal transduction. The International Radiation Hybrid Mapping Consortium mapped the p62 gene to chromosome 5q35. Park et al.(1995) found that the p56-lck SH2 domain binds to p62 at the ser59 of p62 only when that serine is phosphorylated. Joung et al.(1996) expressed epitope-tagged p62 in Hela cells and showed that the expressed protein bound to the lck SH2 domain and that this binding was dependent on the N-terminal 50 amino acids of p62 but not on the tyrosine residue in this region.
ImmunogenA synthetic peptide corresponding to a sequence at the N-terminus of human SQSTM1(91-110aa KDDIFRIYIKEKKECRRDHR), different from the related rat and mouse sequences by one amino acid.
Other NamesSequestosome-1;EBI3-associated protein of 60 kDa;EBIAP;p60;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;Ubiquitin-binding protein p62;SQSTM1;ORCA, OSIL;
Gene, Accession #SQSTM1, UniProt: Q13501
Catalog #PA1955
Order / More InfoSQSTM1/p62 Antibody from BOSTER BIO
Product Specific Referencesn/a
3942 B Valley Ave
Pleasanton CA 94566
P: (888) 466-3604
F: (925) 215-2184



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