PD-1 Antibody from DIANOVA GmbH

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Antigenic SpecificityPD-1
CloneNAT105
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatpurified
Size500 µl
Concentrationn/a
ApplicationsIHC, Paraffin Sections (FFPE), Frozen Sections, Western Blot, Immunoprecipitation, Immunofluorescence, Flow Cytometry
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DescriptionAnti-PD-1 antibody clone NAT105 is suitable for the immunohistological detection of Follicular helper T cells (TFH), Tumor-infitrating T cells (TILs) whose anti-tumor activity is inhibited by PD-1, Lymphomas derived from TFH cells including Angioimmunoblastic T-cell lymphoma, Primary cutaneous CD4-positive small/medium T-cell lymphoma, Follicular variant of peripheral T-cell lymphoma NOS. Moreover, monoclonal antibodies to PD1 and PDL1 are currently being investigated in clinical trials for their potential to inhibit this pathway with the effect of elevated tumor immunity - Background: PD-1 plays a key role in peripheral tolerance and autoimmune disease. Several tumors express ligand for PD1 (PDL1). On binding activated T cells in the tumor microenvironment, PD-1 inactivates antigen specific T cells that would other-wise attack tumor cells.
ImmunogenTY cells (human T/NK Leukemia)
Other NamesProgrammed Cell Death 1, PD-1, CD279, PDCD1, SLEB2
Gene, Accession #PDCD1, 5133
Catalog #DIA-PD1-P01
Priceplease inquire
Order / More InfoPD-1 Antibody from DIANOVA GmbH
Product Specific ReferencesExpression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma.Roncador, G., Verdes-Montenegro, J.F.G., Tedoldi, S., Paterson, J.C., Klapper, W., Ballabio, E., Maestre, L., Pileri, S., Hansmann, M.L., Piris, M.A., Mason, D.Y., Marafioti, T. Haematologica. 2007 Aug;92(8):1059-66.
DIANOVA GmbH
DIANOVA GmbH
DIANOVA GmbH
Warburgstr. 45
20354 Hamburg GERMANY
P: +49 (0)40 / 45067-0
F: +49 (0)40 / 45067-490

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