Integrin beta-1 Antibody from HUABIO INC.

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Antigenic SpecificityIntegrin beta-1
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
FormatProtein A purified
Concentration1 mg/mL
ApplicationsWB, IHC, FC
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DescriptionIntegrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Immunogenrecombinant protein
Other Namesn/a
Gene, Accession #n/a
Catalog #ET1602-10
Order / More InfoIntegrin beta-1 Antibody from HUABIO INC.
Product Specific References1. Szeto HH et al. Improving mitochondrial bioenergetics under ischemic conditions increases warm ischemia tolerance in the kidney. Am J Physiol Renal Physiol 308:F11-21 (2015). 2. Bayer ML et al. Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype. PLoS One 9:e86078 (2014).

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