GAD65 Antibody from INVITROGEN ANTIBODIES

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Antigenic SpecificityGAD65
Clone144
Host SpeciesMouse
Reactive Specieshuman, mouse, rat
IsotypeIgG1
Formatpurified
Size100 µL
Concentrationn/a
ApplicationsFlow Cytometry: Assay-dependent, Immunoprecipitation: Assay-dependent, Radioimmune Assays: Assay-dependent, Western Blot: 1 µg/mL
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DescriptionGAD65 Monoclonal Antibody (144). Antibodies to glutamic acid decarboxylase-65 (GAD65) are present in autoimmune disorders such as insulin-dependent (type1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD.
Immunogenn/a
Other NamesGlutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase 65 kDa isoform; 65 kDa glutamic acid decarboxylase
Gene, Accession #Entrez: 14417, 24380, 2572; Uniprot: P48320, Q05329, Q05683
Catalog #MA5-18053
Price$431
Order / More InfoGAD65 Antibody from INVITROGEN ANTIBODIES
Product Specific ReferencesPubMed: 25800737
INVITROGEN ANTIBODIES
INVITROGEN ANTIBODIES
INVITROGEN ANTIBODIES
by Thermo Fisher Scientific
81 Wyman Street
Waltham MA 02451
P: 800-678-5599
F: 800-331-2286

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