PIEZO1 Antibody from INVITROGEN ANTIBODIES

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Antigenic SpecificityPIEZO1
Clone2-10
Host SpeciesMouse
Reactive Specieshuman, mouse
IsotypeIgG2a
Formatunconjugated
Size100 µL
Concentrationn/a
ApplicationsImmunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50-1:200, Immunohistochemistry: 1:50-1:200, Western Blot: 1:500-1:2,000
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DescriptionPIEZO1 Monoclonal Antibody (2-10). Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel, and generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer. Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, Piezo1 may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Piezo1 acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation and plays a key role in blood vessel formation and vascular structure in both development and adult physiology. The protein encoded by the Piezo1 gene is a mechanically-activated ion channel that links mechanical forces to biological signals. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. Diseases associated with PIEZO1 include Dehydrated Hereditary Stomatocytosis with/without Pseudohyperkalemia And/Or Perinatal Edema and Lymphedema.
Immunogenn/a
Other Namesn/a
Gene, Accession #Entrez: 234839, 9780; Uniprot: E2JF22, Q92508
Catalog #MA5-32876
Price$325
Order / More InfoPIEZO1 Antibody from INVITROGEN ANTIBODIES
Product Specific Referencesn/a
INVITROGEN ANTIBODIES
INVITROGEN ANTIBODIES
INVITROGEN ANTIBODIES
by Thermo Fisher Scientific
81 Wyman Street
Waltham MA 02451
P: 800-678-5599
F: 800-331-2286

customerservice@lifetech.com
Technical Support: techsupport@lifetech.com

https://www.thermofisher.com

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