CD143 (ACE), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD143 (ACE), Human |
| Clone | REA522 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD143 (ACE) Antibody, anti-human, APC, REAfinity™. Clone REA522 recognizes the human CD143 antigen, a single-pass type I membrane protein, which is also known as angiotensin-converting enzyme (ACE). CD143, which exists in two isoforms (a 170 kDa somatic form and a 90 kDa germinal form), is part of the renin-angiotensin system (RAS), and increases blood pressure by causing blood vessels to constrict. It is secreted by cells in the endothelium of blood vessels in lungs and kidneys. The function of CD143 is to catalyse the conversion of angiotensin I to angiotensin II, which are also part of RAS. CD143 is highly regulated in different diseases, for example, sarcoidosis, acute hepatits, diabetis mellitus, multiple myeloma, and osteoarthritis. The somatic form is expressed by endothelial cells (especially those of arterioles and lung capillaries), epithelial cells (especially in proximal renal tubules and in the small intestine), by some neuronal cells, and variably on some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa. Furthermore CD143 is expressed by hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues. | Additional information: Clone REA522 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ACE, ACE1, DCP, DCP1, ICH, MVCD3, Kininase II |
| Gene, Accession # | Gene ID: 1636 |
| Catalog # | 130-108-014 |
| Price | $142 |
| Order / More Info | CD143 (ACE), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Jokubaitis, V. J. et al. (2008) Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues. Blood 111: 4055-4063. | Soubrier, F. et al. (1988) Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9386-9390. | Rohrbach, M. S. (1982) Pulmonary sarcoidosis and serum angiotensin-converting enzyme. Mayo Clin. Proc. 57 (1): 64-66. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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