ERK2, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | ERK2, Human/Mouse |
| Clone | REA186 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ERK2 Antibody, anti-human/mouse, PE, REAfinity™. Clone REA186 recognizes ERK2, a 42 KDa serine/threonine protein kinase, which participates in the MAPK signal transduction pathway. It is involved in regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription. ERK2 and the related kinase ERK1 are phosphorylated by kinases MEK1/2, leading to activation and nuclear translocation of ERKs, where they phosphorylate downstream targets, such as transcription factors including Ets, Elk, and c-Fos. ERK2 activation and mobilization is induced in reponse to several extracellular signals and engagement of receptors such as Tyr kinases (RTKs), G protein-coupled receptors (GPCRs), ion channels, and others. The ERK1/2 are dual specificity kinases and phosphorylate Ser or Thr residues neighbor to proline residue. | Additional Information: Clone REA186 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | MAPK1, ERK, ERK-2, ERT1, MAPK2, P42MAPK, p38, PRKM1, PRKM2 |
| Gene, Accession # | Gene ID: 5594 |
| Catalog # | 130-101-203 |
| Price | $110 |
| Order / More Info | ERK2, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Davis, R. J. et al. (1995) Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42 (4): 459-467. | Roskoski, R. et al. (2012) ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol. Res. 66 (2): 105-143. | Lloyd, A. C. (2006) Distinct functions for ERKs? J. Biol. 5 (5): 13. | Gonzalez-Perez, G. and Lamouse-Smith, E. S. (2017) Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8+ T cell receptor signaling. Front Immunol 8 (8): 265. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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