PKCα, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityPKCα, Human
CloneREA156
Host SpeciesRecombinant Human
Reactive Specieshuman, mouse, rat, other
IsotypeIgG1
Formatphycoerythrin (PE) conjugate
Size30 tests in 60 µL
Concentration1:50
ApplicationsIntracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
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DescriptionPKCα Antibody, anti-human, PE, REAfinity™. Clone REA156 recognizes the PKCα antigen regardless of its phosphorylation status. It has been reported to cross-react with PKCβ. PKCα is a serine- and threonine-specific protein kinase that can be activated by calcium and the second messenger diacylglycerol. It plays a role in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. PKCα is highly expressed in a number of cancer cells where it can acts as a tumor promoter and it is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca 2)+ handling in myocytes. | Additional information: Clone REA156 displays negligible binding to Fc receptors. |
Immunogenn/a
Other NamesPRKCA, AAG6, PKC-alpha, PRKACA, PKC-A
Gene, Accession #Gene ID: 5578
Catalog #130-126-416
Price$110
Order / More InfoPKCα, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesKoivunen, J. et al. (2006) Protein kinase C (PKC) family in cancer progression. Cancer Lett. 235 (1): 1-10. | Finkenzeller, G. et al. (1990) Sequence of human protein kinase C alpha. Nucleic Acids Res. 18 (8): 2183. | Xu, H. et al. (2008) Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. Cardiovasc. Res. 78 (2): 349-355.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

macs@miltenyibiotec.de

https://www.miltenyibiotec.com

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