CD271 (LNGFR), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD271 (LNGFR), Human
CloneME20.4-1.H4
Host SpeciesMouse
Reactive Specieshuman, nonhuman primate, other
IsotypeIgG1κ
Formatbiotin conjugate
Size30 tests in 60 µL
Concentration1:50
ApplicationsFlow cytometry
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DescriptionCD271 (LNGFR) Antibody, anti-human, Biotin. Clone ME20.4-1.H4 recognizes the CD271 antigen, also known as low-affinity nerve growth factor receptor (LNGFR) or neurotrophin receptor (p75 NTR). CD271 belongs to the low-affinity neurotrophin receptors and the tumor necrosis factor receptor superfamily. Initially the human CD271 (LNGFR) was described to be expressed on cells of the central and peripheral nervous system, and was suggested to be involved in the development, survival, and differentiation of cells. 1) | CD271 (LNGFR) is expressed on | • Mesenchymal stem/stromal cells (MSCs)2,3,4 | • Follicular dendritic cells 5) | • Mesenchymal cells involved in mesenchymal-epithelial interactions 6) | • Autonomic and sensory Neurons 7) | • Oligodendrocytes 8) | • Astrocytes 9) | • Schwann cells10,11 | • Neural crest stem cells 12)
Immunogenn/a
Other NamesNGFR, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, p75NGFR, NGFR (p75)
Gene, Accession #Gene ID: 4804
Catalog #130-113-981
Price$93
Order / More InfoCD271 (LNGFR), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesCaneva, L. et al. (1995) Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies. Blood Cells Mol. Dis. 21: 73-85. | Quirici, N. et al. (2002) Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies. Exp. Hematol. 30: 783-791. | Casaccia-Bonnefil, P. et al. (1996) Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 383: 716-719. | DiStefano, P. S. and Johnson, E. M. Jr. (1988) Identification of a truncated form of the nerve growth factor receptor. Proc. Natl. Acad. Sci. U.S.A. 85: 270-274. | Civenni, G. et al. (2011) Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth. Cancer Res. 71 (8): 3098-57363109. | Huber, L. J. and Chao, M. V. (1995) Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanisms. Dev. Biol. 167: 227-238. | Chalazonitis, A. et al. (1998) Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRalpha-1 in vitro and in vivo. Dev. Biol. 204 (2): 385-406. | Jones, E. A. et al. (2002) Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum 46: 3349-3360. | Kashiba, H. et al. (1995) Coexpression of trk family members and low-affinity neurotrophin receptors in rat dorsal root ganglion neurons. Brain Res. Mol. Brain Res. 30: 158-164. | Rudge, J. S. et al. (1994) Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes. Eur. J. Neurosci. 6: 693-705. | Thomson, T. M. et al. (1988) Expression of human nerve growth factor receptor on cells derived from all three germ layers. Exp. Cell Res. 174: 533-539. | Pezzati, P. et al. (1992) Expression of nerve growth factor receptor immunoreactivity on follicular dendritic cells from human mucosa associated lymphoid tissues. Immunology 76: 485-490. | Rozemuller, H. et al. (2010) Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies. Stem Cells Dev. 19: 1911-1921. | Vroemen, M. and Weidner, N. (2003) Purification of Schwann cells by selection of p75 low affinity nerve growth factor receptor expressing cells from adult peripheral nerve. J. Neurosci. Methods 124: 135-143.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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